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Since chromosome segregation is driven by microtubules, colchicine is also used for inducing polyploidy in plant cells during cellular division by inhibiting chromosome segregation during meiosis; half the resulting gametes, therefore, contain no chromosomes, while the other half contains double the usual number of chromosomes i.
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3 6 during the initiation of febuxostat therapy, adverse effects from concurrent use of colchicine nausea, vomiting, and, rarely, neutropenia or nonsteroidal anti-inflammatory drugs nsaids; gastrointestinal distress, ulcers, and renal dysfunction are possible.
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It inhibits motility of polymorphonuclear leukocytes, similar to colchicine it uncouples oxidative phosphorylation in cartilaginous and hepatic mitochondria, like salicylates decreased cerebral blood flow see below .
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In previous drug metabolism studies in rats, colchicine has been shown to undergo extensive hepatic metabolism, and parent and metabolites are eliminated mainly by biliary excretion hunter and klaassen, 1975; sabouraud et al.
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In 2009 though, the fda gave url pharma a three-year exclusivity to manufacture and market colchicine for gout and a few other indications.
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